top of page
Brain Blog


Just Start: Why the Hardest Part of Exercise for Your Brain Is Lacing Up the First Time
I know what happens when I bring up exercise in the clinic during appointments with my patients. There is a particular look. A slight shift in the chair. Sometimes a polite nod that communicates, clearly, that this conversation has been had before and that it did not result in a gym membership. I understand it. The word "exercise" carries decades of cultural baggage — images of early mornings, discomfort, athletic ability that was never there to begin with, and a time commit
Michael K. Lowe, MD
5 days ago5 min read


The Night Shift: Why Sleep May Be Your Brain's Most Powerful Protective Tool
I want to tell you about a conversation I have frequently in my resident clinic. A patient comes in concerned about memory. They're forgetting names, losing their train of thought mid-sentence, feeling mentally foggy in a way that wasn't there a few years ago. We go through the workup. And somewhere in the history, frequently as an afterthought, they mention that they haven't been sleeping well for years. They wake up at 3 am and can't get back down. Or they're in bed for ei
Michael K. Lowe, MD
Mar 225 min read


The Diagnosis Your Doctor Might Be Missing: Understanding LATE
There is a conversation I have had a few times in the last several months in my resident clinic that I believe is worth blogging about. A family comes in — often adult children accompanying a parent in their mid-to-late eighties — and they describe a pattern that has been quietly unfolding for years. The memory has been slipping. Slowly. Names, recent conversations, why they walked into a room. But the person sitting across from me can still tell me where they vacationed in 1
Michael K. Lowe, MD
Mar 157 min read


The Heart-Brain Highway: Why Your Cardiologist and Your Neurologist Should Be Friends
I want to tell you about a patient I see more often than you might think. She comes in worried about her memory. She's been forgetting names. She walked into the kitchen last week and couldn't remember why. Her family is concerned. And when I sit across from her with her MoCA results and her chart, I notice something that never surprises me anymore: her blood pressure has been quietly elevated for years. Her last echocardiogram showed reduced ejection fraction. Nobody connect
Michael K. Lowe, MD
Mar 85 min read


The MIND Diet for People Who Are Too Busy To Change Their Diet
If you are caring for a loved one in cognitive decline, the last thing you need is a 20-step recipe involving fancy ingredients you can’t even find at your local grocery store. You are already managing medications, appointments, and daily safety; the idea of "overhauling" a pantry feels impossible. However, the MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) is widely considered the "gold standard" of nutritional neuroscience for a reason: it works. R
Michael K. Lowe, MD
Mar 14 min read


The Efficacy and Safety of Conventional Alzheimer’s Medications (The "Big 4")
In the world of Alzheimer’s research, we often get caught up in the hunt for the "miracle cure"—the breakthrough drug that will stop neurodegeneration in its tracks. Because the current standard-of-care medications don't do that, they often get a bad, or at least boring, reputation. You may have heard them described as "minimally effective" or "not worth the side effects." However, in clinical practice, I see a different story. I’ll dub them the "Big 4"—Donepezil (Aricept),
Michael K. Lowe, MD
Feb 224 min read


The Hidden Link: Why Depression May Be the Earliest Warning Sign of Dementia
For decades, we viewed the aging brain through a narrow lens. We saw "memory loss" as the starting line for Alzheimer’s and "mood changes" as a secondary byproduct of getting older. But the emerging science tells a much more proactive story. We now know that the link between depression and dementia is not just real—it is foundational. In many cases, depression isn't just a reaction to losing one's memory; it is a "pre-clinical" symptom—a biological red flag that appears year
Michael K. Lowe, MD
Feb 153 min read


Beyond the Playlist: Why Music is a "Multi-Vitamin" for the Brain
If I told you there was a new drug that could simultaneously lower cortisol, improve gait and balance, trigger deep-seated memories in non-verbal patients, and stimulate neuroplasticity in the hippocampus—all with zero side effects—it would be the lead story on every news cycle. That "drug" actually exists. It’s music. However, we need to move past the idea/misunderstanding that music therapy is just putting headphones on a patient and walking away. While passive listening
Michael K. Lowe, MD
Feb 74 min read


Why the MoCA is the "Special Ops" Tool of Cognitive Screening: A 2026 Guide for Families
In the high-stakes world of neurology, we often get caught up in the "glamour" of $5,000 PET scans and the latest monoclonal antibody infusions like Leqembi and Kisunla . But as a resident clinician, the most important ten minutes of my day aren’t spent looking at a computer screen—they are spent sitting across from a patient with a single sheet of paper and a pen. That single sheet of paper is the Montreal Cognitive Assessment (MoCA) . I recently became officially accredi
Michael K. Lowe, MD
Jan 315 min read


Leqembi and Kisunla: Two Years Later, What Have We Actually Learned?
In the world of neurodegeneration, we mark time by the "before" and the "after." For twenty years, we lived in the "before"—an era where our only tools were medications that masked symptoms without touching the underlying disease. Then, in 2023 and 2024, the landscape shifted. With the arrival of Leqembi (lecanemab) and Kisunla (donanemab) , we entered the "after." I have long maintained that these drugs represent a monumental leap forward—not because they are "cures," but
Michael K. Lowe, MD
Jan 243 min read


The "Dementia Umbrella": Why the Label Matters More Than You Think
In my resident clinic, I often meet families who are confused when I don't immediately use the "A-word." They’ve noticed a loved one is struggling, and they’ve already jumped to the conclusion that it’s Alzheimer’s. When I explain that we are looking at something else—perhaps Vascular Dementia or Lewy Body Dementia—the reaction is often a mix of relief and confusion. "Isn't that just another name for Alzheimer's?" they ask. The answer is a firm no . Dementia is not a single
Michael K. Lowe, MD
Jan 184 min read


The Rise of At-Home Alzheimer’s Testing: Empowerment or Uncertainty?
The landscape of modern healthcare is shifting toward shared accountability. We see it in the explosion of wearable fitness trackers and the availability of at-home kits for everything from cholesterol to colon cancer screening. It was only a matter of time before this trend reached the world of memory care. Today, the "Black Box" of neurology is opening. Patients no longer have to wait for a specialist appointment to begin investigating their cognitive health. However, as a
Michael K. Lowe, MD
Jan 114 min read


Diabetes medications for treating dementia ... did I hear that correctly?
In the field of neurology, we are often forced to manage expectations as much as we manage symptoms. For decades, the search for effective Alzheimer’s treatments has been marked by more setbacks than breakthroughs. However, a new area of study is gaining significant momentum in the research community, centered on a surprising class of medications: those originally designed to treat Type 2 Diabetes (DM2). While the headlines are full of "new hope," as a provider, it is my res
Michael K. Lowe, MD
Jan 44 min read
bottom of page